Immunomodulatory action of intravenous immunoglobulin

Uses of intravenous immunoglobulin

Adjuvant high dose IVIgs are being used increasingly in a range of immune-mediated and auto-immune diseases. Although numerous immunomodulatory mechanisms have been suggested, the exact mechanisms of action are poorly understood. The efficacy of IVIg in certain diseases has been proven in clinical trials, in so far as IVIg is approved as the therapy of choice for Kawasaki syndrome and idiopathi...

Mechanism of action of intravenous immunoglobulin in immune-mediated cytopenias.

High dose intravenous immunoglobulin treatment: mechanisms of action.

Intravenous immunoglobulin (IVIg) treatment was introduced as replacement therapy for patients with antibody deficiencies, but evidence suggests that a wide range of immune-mediated conditions could benefit from IVIg. The immunoglobulins are precipitated from human plasma by fractionation methods. In conclusion, the differences in basic fractionation methods and the addition of various modifica...

Clinical Application and Functional Mechanisms of Intravenous Immunoglobulin: an Overview

Previous, Intravenous Immunoglobulin (IVIG) has been used for treatment of patients with immunodeficiency. However, recent studies have shown that IVIG is a suitable approach for treatment of inflammatory and autoimmune diseases. Although the exact mechanism of IVIG action is not well known, recent findings have demonstrated that IVIG impacts on expression and function of FC receptors of immuno...

Applications of intravenous immunoglobulin.

Intravenous immunoglobulin (IV Ig) preparations allow large amounts of IgG to be administered rapidly and painlessly. Currently, there are a number of IV IgG preparations available which differ in their manufacturing methods. However, all the licensed preparations are associated with a low incidence of adverse reactions on administration. They are used mainly for IgG replacement therapy in pati...